E.J. McCarthy

The effects of genetic engineering on biomechanic output

My work focuses on investigating the mechanics of engineered biosystems. Since the sequencing of the human genome in 2001, humanity has had the benefit of a standardised reference template for its genetic code. This reference eventually inspired the development of precision gene editing techniques such as TALENs and CRISPR/Cas9 , which have been utilised to create customised genes and genomes in a variety of organisms. The next big step in the field of bioengineering is to probe just how these customised genomes manifest themselves as phenotypes, and to what extent. With the support of the Oyen Lab, I plan to utilise various physical and mechanical parametric phenotypes of biological systems such as strength, toughness, and elasticity to assess the impact of different genetic and environmental perturbations. This work should have a wide array of interdisciplinary academic and industrial applications in the fields of biology, chemistry, physics, engineering, medicine, and computational science.